信號轉導因子和轉錄激活因子3 (phospho Tyr705)多克隆抗體

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產(chǎn)品英文名稱(chēng)	Stat3 (phospho Tyr705) Polyclonal Antibody
免疫原	合成多肽：人源蛋白Stat3，磷酸化多肽，中心氨基酸為Y705.
宿主	兔
反應性	人, 大鼠, 小鼠
應用	ELISA, IF, IHC-P, IP, WB
實(shí)驗建議	最佳的工作稀釋比例需要客戶(hù)摸索優(yōu)化。建議的起始嘗試的稀釋比為：WB：1:500-1:2000，IHC-p：1:100-1:300。 IP：2-5 ug/mg lysate。 ELISA：1:20000。尚未在其他應用中測試。
克隆性	多克隆
純化工藝	使用表位特異性的免疫原，通過(guò)親和層析，從兔抗血清中親和純化抗體。

產(chǎn)品形式	液體溶液
濃度	1 mg/ml
儲存緩沖液	含有50％甘油，0.5％BSA和0.02％疊氮化鈉的PBS緩沖液。
保存建議	自發(fā)貨之日起，-20°C可穩定保存1年。為最大限度的避免損失，請在打開(kāi)管蓋之前融化抗體并離心。我們建議使用前分裝以避免反復凍融。
運輸條件	藍冰運輸
警告	本文列出的產(chǎn)品僅供研究使用，不適用于人類(lèi)或臨床診斷。我們產(chǎn)品所推薦應用，不是建議使用我們的產(chǎn)品去違反任何專(zhuān)利或許可證。對于使用本產(chǎn)品可能發(fā)生的專(zhuān)利侵權或其他違規行為，我們不承擔任何責任。

背景	Signal transducer and activator of transcription 3 encoded by STAT3 is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. Signal transducer and activator of transcription 3 is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. Signal transducer and activator of transcription 3 mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in STAT3 are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
基因ID	6774
別名	STAT3; APRF; Signal transducer and activator of transcription 3; Acute-phase response factor
其它	該抗體可檢測內源蛋白
蛋白質(zhì)ID	P40763
目標條帶分子量（KD)	88